G Protein–Coupled Receptor G2A

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.

G2A (from G2 accumulation) is a G-protein-coupled receptor (GPCR) that regulates the cell cycle, proliferation, oncogenesis, and immunity. G2A shares significant homology with three GPCRs including ovarian cancer GPCR (OGR1/GPR68), GPR4, and T cell death-associated gene 8 (TDAG8). Lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC) were reported as ligands for G2A and GPR4 and f...

The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.

G2A, a G protein-coupled receptor for which lysophosphatidylcholine (LPC) is a high affinity ligand, belongs to a newly defined lysophospholipid receptor subfamily. Expression of G2A is transcriptionally up-regulated by stress-inducing and cell-damaging agents, and ectopic expression of G2A leads to growth inhibition. However, the G proteins that functionally couple to G2A have not been elucida...

G protein-coupled receptor G2A: friend or foe of the vasculature?

Atherosclerosis is, in large part, an inflammatory process. White blood cells of different lineages are essential components of the atherosclerotic plaque. More important than their numbers, white blood cells influence the structure of an atherosclerotic plaque, and the function of the vessel in which the plaque is present, by secreting a host of agents that affect resident vascular cells.1 Mac...

G-protein Coupled Receptor Dimerization

A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...